Journal Name:
Am J Clin Nutr
Article Title:
Comparison of the effectmof canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men
Date Written:
1989
Volume:
50
Number:
Page:
1382
Author(s):
McDonald, B.; Gerrard, J.; Bruce, V.; Corner, E.
Article:
This study was one of the first investigations to assess the effects of the unique fatty acid profile of CO on plasma lipids and eicosanoid production. Eight normolipidemic men were fed a diet in which approximately 75% of the fat was provided by a mixture of fats (MF) for a 6 day pre and post-experimental period. Experimental diets were comprised of either CO or sunflower oil (SO) during two 18 day experimental periods. Four subjects were assigned at random to the CO diet and the other four to the SO diet during the first experimental period. Subjects consumed the diets in the opposite sequence during the second experimental period. SFAs, MUFAs and PUFAs provided 14%, 15%, and 7%; 5%, 20%, and 10%; and 7%, 7%, and 22%, respectively, of total dietary energy in the MF, CO, and SO diets, respectively.
The authors reported that the CO and SO diets produced similar significant decreases in plasma total cholesterol (20% and 15%, respectively) and LDL-C (25% and 21%, respectively). Plasma HDL-C, VLDL-C and triglyceride concentrations were not altered by either fat source. Bleeding times were significantly longer following both the CO and SO diets in comparison to the MF diet. However, in vivo 6-keto-PGF1( production, the stable blood metabolite of the anti-thrombotic eicosanoid prostacyclin, was significantly greater only following the CO diet. The authors speculated that the higher levels of ALA in CO (10% of total fatty acids) may be responsible for these observations. Mean levels of the pro-thrombotic eicosanoid, thromboxane B2, decreased following both diets. Mean systolic blood pressure was lower after both diets than after the MF diet, but the differences were not statistically significant. The results of this study confirm previous research that has shown OA to be effective in reducing blood cholesterol levels. This study provides strong support for the hypocholesterolemic and antithrombotic effects of CO., , , , ,
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